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KMID : 1146920190490010045
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Journal of Pharmaceutical Investigation
2019 Volume.49 No. 1 p.45 ~ p.55
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Tailoring of anticancer drugs loaded in MWCNT/Poly(MMA-co-HEMA) nanosphere composite by using in situ microemulsion polymerization
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Sobh R. A.
Nasr H. E.
Moustafa A. B.
Mohamed W. S.
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Abstract
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Synthesis of multi-walled carbon nanotube (MWCNT)/Poly(methyl methacrylate-co-2-hydroxyethyl methacrylate) P(MMA-co-HEMA) nanocomposite loaded with either of curcumin and its water soluble derivative as two models of anticancer drugs was achieved via in situ microemulsion polymerization technique by using different ratios from multi-walled carbon nanotube MWCNT to drug. The homogenous dispersion of MWCNTs inside the polymer matrix and well defined nano-spheres were proved by TEM and X-ray diffraction XRD. The performance of MWCNT/polymer nanocomposite as drug carrier was examined with respect to the drug content, entrapment efficiency, nano-sphere morphology, thermal stability and in-vitro drug release. Drugs could be loaded in higher content with high Entrapment Efficiency values with improved thermal stability that increased with MWCNT ratio. The in-vitro drug release studies from MWCNT/Poly(MMA-co-HEMA) nanocomposite showed prolonged controlled release in the intestinal fluid pH 7.4 and lost a few amount?≤?8% of the drug in the stomach fluid pH 1.2.
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KEYWORD
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MWCNTs/polymer nanocomposite, Micro-emulsion polymerization, Anticancer drugs
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